Batubara regency, North Sumatra province, Indonesia

Approach to USD 40.000

Walter and Eliza Hall Institute

Walter and Eliza Hall Institute (Autralia), Oxford University Clinical Research Unit (Jakarta), Univesity of Indonesia (Jakarta), Universitas Sumatera Utara ( Medan ), Rumah Sakit Umum Daerah Kabupaten Mimika (Papua)

In order to eliminate P. vivax within proposed timeframes (i.e. by 2030) it is essential to directly target the ‘silent’ hypnozoite reservoir sustaining P. vivax transmission. Modelling studies show that population mass-screening and treatment (MSAT) of parasite positive individuals will not have a persistent effect on P. vivax transmission even if screening is done by PCR. While MDA including an anti-hypnozoitocidal drug such a primaquine is predicted to be highly effective against P. vivax, this is logistically challenging: G6PD testing is required to prevent the potentially severe haemolysis associated with 8- aminoquinoline treatment in G6PD-deficient people and directly observed treatment (DOTs) is needed to assure treatment success.

A.  Primary objective: to determine the efficacy of a Serological Screening and Treatment (SSAT) intervention for the prevention of recurrent P. vivax malaria.

B. Secondary objectives:

1. To evaluate the performance of a point-of-care (POC) anti-P. vivax antibody detection test relative to Luminex (MagPix).
2. To evaluate safety of high dose PQ administration in school children.
3. To evaluate the accuracy of Sahli’s method and Standard G6PD (SD Biosensor Inc., Deogyeong-daero, Korea) relative to HemoCue for haemoglobin measurement.
4. To estimate the sensitivity and specificity of a microscopic diagnosis of blood by sample from skin (ankle) relative to standard finger stick microscopic and PCR.
5. To measure duration of gametocyte in the blood samples of the skin of the ankle and finger prick.
6. To estimate the sensitivity and specificity of magneto-optical of hemozoin detection by Gazelle® (Hemex Health, USA) relative to standard finger stick microscopic and PCR.
7. To analyse hemoglobin opathies in school children using Gazelle (Hemex Health, USA).

Under Analysis