Bunda Thamrin and Murni Teguh Hospital Medan

 Approach to USD 114.000

Oxford University

Oxford University (UK), Oxford University Clinical Research Unit (Jakarta)

Currently, the world is experiencing an unprecedented pandemic of COVID-19 / SARS￾CoV-2, which emerged at the end of 2019 in Wuhan, China, and has subsequently  spread to almost all countries in the world, causing severe disruption across all sectors,  including shutdown of large parts of the economy and implementation of social  distancing measures to prevent or mitigate transmission. The global COVID-19/SARS￾CoV-2 pandemic disproportionately affects low- and middle-income countries (LMIC),  but rigorous research of its clinical management and consequences in those settings.

is lacking. Indonesia, with the fourth largest population (270 million) globally, is facing  tremendous challenges, particularly in its capital Jakarta. Systematic approaches are urgently needed to “learn-as-we-go” by characterizing clinical patterns, management and outcomes of hospitalised COVID-19 patients, analysed in an international context and rapidly reported back to frontline clinicians and policy.

makers, in order to improve the constantly evolving national response.

1. Primary Objectives

In patients and contacts meeting the entry criteria, our primary objectives are to: 

•  Describe the clinical features of the illness or syndrome and identify risk factors for severe disease.
•  Describe the response to treatment, including supportive care and novel therapeutics. 
•  Observe, where appropriate and feasible, pathogen replication, excretion and evolution, within the host, and identify determinants of severity and transmission using high-throughput sequencing of pathogen genomes obtained from respiratory tract, blood, urine, stool and other samples.
•  Characterise, where appropriate and feasible, the host responses to infection and therapy over time, including innate and acquired immune responses, circulating  levels of immune signalling molecules and gene expression profiling in peripheral blood.
•  Identify biomarkers and host genetic variants associated with disease progression or severity.
•  Understand household transmissibility and the probabilities of different clinical outcomes following exposure and infection.
  
  

  2. Secondary Objectives

Secondary objectives are to collect evidence in order to:

• Facilitate effective triage and clinical management of patients with infections relevant to this protocol.
•  Determine infectivity and appropriate infection control measures of the various pathogens.
•  Develop clinical guidance documents and offer clinical recommendations to policy makers on the basis of evidence obtained.
•  Understand the broader epidemiology of an emerging infection through studying potential contacts and asymptomatic individuals.

Under analysis